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Teratogenic effect of Disodium 5’ Ribonucleotide (E635) on 15th day chick embryo Gallus gallus (Research note) | ||
| Poultry Science Journal | ||
| مقاله 2، دوره 13، شماره 2، شهریور 2025، صفحه 151-158 اصل مقاله (973.72 K) | ||
| نوع مقاله: Research Note | ||
| شناسه دیجیتال (DOI): 10.22069/psj.2024.22849.2173 | ||
| نویسندگان | ||
| Shaiba Iqbal Sharikmaslat* ؛ Nitin Anandrao Kamble | ||
| Department of Zoology, Shivaji University, Kolhapur-416004, Maharashtra, India | ||
| چکیده | ||
| Disodium 5' ribonucleotide (E635), commonly used as a food additive, may pose teratogenic risks. The study aimed to evaluate the teratogenicity of disodium 5’ ribonucleotide using chick embryos as an in vivo model. Fertilized chicken eggs were inoculated with LD50 dose of 0.05 µg/egg of disodium 5’ ribonucleotide on the 0th, 5th, and 10th days of embryonic development. The control group received 0.05 mL of distilled water on the 0th, 5th, and 10th days. After 15 days of incubation, embryos were examined for morphological abnormalities. The disodium 5’ ribonucleotide inoculated embryos exhibited significant developmental anomalies, including acrania, monophthalmia, bent toes, curved beak, scissor beak, omphalocele, and hematoma, compared to the control group. These abnormalities were categorized and analyzed through morphometric assessments to evaluate their severity. Data were subjected to statistical analysis using t-test to find out significance of developmental anomalies in dose induced group and control group animals. Anatomical changes indicated that disodium 5’ ribonucleotide exposure led to severe teratogenic effects in chick embryos, which has highlighted potential risks associated with its use as a food additive. | ||
| کلیدواژهها | ||
| food additiveو teratogenicityو Gallus gallusو developmental deformity 15th day of chicken embryo | ||
| مراجع | ||
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