آمار
| تعداد نشریات | 14 |
| تعداد شمارهها | 692 |
| تعداد مقالات | 7,155 |
| تعداد مشاهده مقاله | 11,516,379 |
| تعداد دریافت فایل اصل مقاله | 10,449,560 |
Blood Profiles and Gut Microbial Communities in Broiler Chickens: Are There Any Associations? | ||
| Poultry Science Journal | ||
| دوره 14، شماره 2، بهمن 2026، صفحه 223-242 اصل مقاله (2.7 M) | ||
| نوع مقاله: Original Paper | ||
| شناسه دیجیتال (DOI): 10.22069/psj.2026.24279.2453 | ||
| نویسندگان | ||
| Galimzhan Duskaev1؛ Ludmila Vlasenko* 2؛ Ilshat Karimov3؛ Alexander Zatevalov4؛ Dmitry Deryabin5 | ||
| 1Department of Feeding for Farm Animals and Feed Technology named after S.G. Leushin, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia | ||
| 2Laboratory of Breeding and Genetic Research in Animal Husbandry, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russian Federation | ||
| 3Laboratory of Breeding and Genetic Research in Animal Husbandry, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia Department of Epidemiology and Infectious Diseases, | ||
| 4Laboratory of Breeding and Genetic Research in Animal Husbandry, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia Laboratory for Diagnostics and Prevention of Infectious | ||
| 5Laboratory of Breeding and Genetic Research in Animal Husbandry, Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia | ||
| چکیده | ||
| The general concept of a gut-bone marrow axis, which describes the communication between the microbial community and the hematopoietic system, still has little experimental support in poultry. The goal of this study was to evaluate the hematological values and gut microbial communities in broiler chickens belonging to the globally used Arbor Acres strain and the domestic Smena 8 strain, and to assess the associations between these parameters. The study design included a group-level meta-analysis of homogeneous quantitative hematological and microbiological datasets obtained from 40 independent chicken groups using an automatic 5-diff hematology analyzer and metagenomic sequencing technology performed on the Illumina MiSeq platform. Comparison of blood profiles between Arbor Acres and Smena 8 broiler chicken strains revealed significant (P< 0.001) differences in red blood cells (RBC) and white blood cells (WBC) counts, complemented by less expressed (P= 0.002) differences in platelet (PLT) counts. In turn, a comparison of gut microbiomes showed a common core, represented by 46 bacterial genera and equivalent taxonomic ranks, as well as specific components that are predominantly found (21 genera) or are exclusively characteristic (93 genera) for a particular broiler chicken strain. Subsequent analysis of the associations between blood profiles and microbial communities identified 23 bacterial genera that were strongly positively associated with the WBC and PLT counts or negatively associated with the RBC and WBC counts. Overall, the present study explained 12.39% of RBC and 22.28% of WBC count variability, and the most pronounced 55.65% PLT variability in blood profiles of broiler chickens as microbiome-related, which should be considered when these parameters are jointly assessed in poultry farming. | ||
| کلیدواژهها | ||
| Blood profile؛ Broiler chicken؛ Gut microbiome | ||
| مراجع | ||
|
Al Hakeem WG, Acevedo Villanueva KY & Selvaraj RK. 2023. The development of gut microbiota and its changes following C. jejuni infection in broilers. Vaccines, 11(3): 595. DOI: 10.3390/vaccines11030595.
Atlanderova KN, Duskaev GK, Rakhmatullin SG & Kvan OV. 2021. Metagenomic analysis of the broiler intestine microbiome against the background of plant extracts and probiotics. FEBS Open Bio, 11: 386. DOI: 10.1002/2211-5463.13205.
Bagirov VA, Ushakov AS, Duskaev GK, Kvan OV, Rakhmatullin SG, Yausheva EV & Vershinina IA. 2020. Metagenomic analysis of intestinal microbiome and biochemical composition of broiler meat upon use of Quercus cortex extract dietary additive. Agricultural Biology, 55(4): 682-696. DOI: 10.15389/agrobiology.2020.4.682eng.
Baudouin KA, Soualio K, Mathieu BN & Angoue Paul Y. 2021. Hematological profile of broilers and local chickens in Korhogo, Cote D'Ivoire. International Journal of Agriculture Environment and Bioresearch, 6(2): 14-23. DOI: 10.35410/IJAEB.2021.5618.
Berg G, Rybakova D, Fischer D, Cernava T, Vergès MC, Charles T, Chen X, Cocolin L, Eversole K, Corral GH, Kazou M, Kinkel L, Lange L, Lima N, Loy A, Macklin JA, Maguin E, Mauchline T, McClure R, Mitter B, Ryan M, Sarand I, Smidt H, Schelkle B, Roume H, Kiran GS, Selvin J, Souza RSC, van Overbeek L, Singh BK, Wagner M, Walsh A, Sessitsch A & Schloter M. 2020. Microbiome definition re-visited: old concepts and new challenges. Microbiome, 8(1): 103. DOI: 10.1186/s40168-020-00875-0.
Bilkova B, Bainova Z, Janda J, Zita L & Vinkler M. 2017. Different breeds, different blood: Cytometric analysis of whole blood cellular composition in chicken breeds. Veterinary Immunology and Immunopathology, 188: 71-77. DOI: 10.1016/j.vetimm.2017.05.001.
Bush JR & Alfa MJ. 2020. Increasing levels of Parasutterella in the gut microbiome correlate with improving low-density lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial. BMC Nutrition, 6(1): 72. DOI: 10.1186/s40795-020-00398-9.
Cowieson AJ. 2022. Comparative biology of germ-free and conventional poultry. Poultry Science, 101(10): 102105. DOI: 10.1016/j.psj.2022.102105.
Deryabin DG, Kosyan DB, Inchagova KS & Duskaev GK. 2023. Plant-derived quorum sensing inhibitors (quercetin, vanillin and umbelliferon) modulate cecal microbiome, reduces inflammation and affect production efficiency in broiler chickens. Microorganisms, 11(5): 1326. DOI: 10.3390/microorganisms11051326.
Deryabin D, Kosyan D, Vlasenko L, Lazebnik C, Zatevalov A, Karimov I & Duskaev G. 2024. Macro, trace and toxic element composition in liver and meat of broiler chicken associated with cecal microbiome community. Biology, 13(12): 975. DOI: 10.3390/biology13120975.
Diaz Carrasco JM, Casanova NA & Fernández Miyakawa ME. 2019. Microbiota, gut health and chicken productivity: what is the connection? Microorganisms, 7(10): 374. DOI: 10.3390/microorganisms7100374.
Dutta RK, Islam MS & Kabir MA. 2013. Haematological and biochemical profiles of Gallus indigenous, exotic and hybrid chicken breeds (Gallus domesticus L.) from Rajshahi, Bangladesh. Bangladesh Journal of Zoology, 41(2): 135-144. DOI: 10.3329/bjz.v41i2.23314.
Duskaev G, Kvan O, Kosyan D, Rakhmatullin S & Levakhin G. 2021. Coumarin derivative and Bacillus cereus change live weight and cecal ecology in broilers. AIMS Agriculture and Food, 6(1): 360-380. DOI: 10.3934/agrfood.2021022.
Duskaev GK, Rakhmatullin SG, Kosyan DB, Rusakova EA, Kvan OV & Levakhin GI. 2022. The effect of the combined use of gamma-octalactone and chlortetracycline in the broiler diet: live weight, feed efficiency and the microbiome of the caecum. Agrarian Science, (9): 47-53. DOI: 10.32634/0869-8155-2022-362-9-47-53.
Duskaev GK, Lazebnik KS & Klimova TA. 2022. Microbial diversity in the cecum of broiler chickens after introduction of coumarin and feed antibiotic into the diet. RUDN Journal of Agronomy and Animal Industries, 17(4): 555-566. DOI: 10.22363/2312-797X-2022-17-4-555-566.
Duskaev GK, Rusakova EA & Deryabin DG. 2022. The using of gamma-octanolactone in the broiler diet: Intestinal microbiome. International Journal of Veterinary Medicine, (4): 152-158. DOI: 10.52419/issn2072-2419.2022.4.152.
Duskaev GK, Vlasenko LV, Kosyan DB & Kurilkina MY. 2023. The effect of small molecules of plant origin on the cecal microbial diversity in broilers. Ptitsevodstvo, 72(4): 46-51. DOI: 10.33845/0033-3239-2023-72-4-46-51.
El Brihi J & Pathak S. 2024. Normal and abnormal complete blood count with differential. In: StatPearls. StatPearls Publishing, Treasure Island, FL, USA.
Emanuylova ZhV, Egorova AV, Efimov DN & Komarov AA. 2021. New highly productive Russian cross of broiler chicken "Smena-9". Agrarian Science, (7-8): 33-36. DOI: 10.32634/0869-8155-2021-351-7-8-33-36.
Fan Z, Ke X, Jiang L, Zhang Z, Yi M, Liu Z, Cao J, Lu M & Wang M. 2024. Genomic and biochemical analysis reveals fermented product of a putative novel Romboutsia species involves the glycometabolism of tilapia. Aquaculture, 581(41): 740483. DOI: 10.1016/j.aquaculture.2023.740483.
Fernandez Sanchez J, Maknojia AA & King KY. 2024. Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease. Blood, 143(17): 1689-1701. DOI: 10.1182/blood.2023021174.
Gurumurthy G, Gurumurthy J, Gurumurthy S, Reynolds L & Thachil J. 2026. Dysbiosis and immunothrombosis - How platelets and the gut microbiome interact. Blood Reviews, 101395. DOI: 10.1016/j.blre.2026.101395.
Idowu PA, Mpofu TJ, Zishiri OT, Oluwamayowa OJ, Nephawe KA & Mtileni B. 2025. Gene sequencing and in silico characterization of mannose-binding lectin in South African chicken breeds. Journal of Advanced Veterinary and Animal Research, 12(3): 941-955. DOI: 10.5455/javar.2025.l955.
Khosravi A, Yanez A, Price JG, Chow A, Merad M, Goodridge HS & Mazmanian SK. 2014. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host & Microbe, 15(3): 374-381. DOI: 10.1016/j.chom.2014.02.006.
Kongpechr S, Sukon P & Sohsuebngarm D. 2021. The study of hematology in commercial broiler chickens of Cobb 500, Ross 308, and Arbor Acres Plus. Journal of Mahanakorn Veterinary Medicine, 15(2): 209-221.
Kovacs R, Arokszállási T, Bozo A, Jakab A, Babel KS, Heja M, Kovacs KB, Balazs B, Vitalis E, Majoros L & Tóth Z. 2024. Bacteraemia associated with Bilophila wadsworthia: A rare case presentation from Hungary. Pathogens, 13(9): 749. DOI: 10.3390/pathogens13090749.
Lee YS, Kim TY, Kim Y, Kim S, Lee SH, Seo SU, Zhou BO, Eunju O, Kim KS & Kweon MN. 2021. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Experimental & Molecular Medicine, 53(9): 1319-1331. DOI: 10.1038/s12276-021-00667-y.
Liu X, Zhang H, Shi G, Zheng X, Chang J, Lin Q, Tian Z & Yang H. 2024. The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment. Frontiers in Immunology, 15: 1338178. DOI: 10.3389/fimmu.2024.1338178.
Lynch JB, Gonzalez EL, Choy K, Faull KF, Jewell T, Arellano A, Liang J, Yu KB, Paramo J & Hsiao EY. 2023. Gut microbiota Turicibacter strains differentially modify bile acids and host lipids. Nature Communications, 14(1): 3669. DOI: 10.1038/s41467-023-39403-7.
Nawaz AH, Setthaya P & Feng C. 2024. Exploring evolutionary adaptations and genomic advancements to improve heat tolerance in chickens. Animals, 14(15): 2215. DOI: 10.3390/ani14152215.
Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y & Wang X. 2021. Roseburia intestinalis: a beneficial gut organism from the discoveries in genus and species. Frontiers in Cellular and Infection Microbiology, 11: 757718. DOI: 10.3389/fcimb.2021.757718.
Nwaigwe CU, Ihedioha JI, Shoyinka SV & Nwaigwe CO. 2020. Evaluation of the hematological and clinical biochemical markers of stress in broiler chickens. Veterinary World, 13(10): 2294-2300. DOI: 10.14202/vetworld.2020.2294-2300.
Paul SS, Chatterjee RN, Raju MVLN, Prakash B, Rama Rao SV, Yadav SP & Kannan A. 2021. Gut microbial composition differs extensively among Indian native chicken breeds originated in different geographical locations and a commercial broiler line, but breed-specific, as well as across-breed core microbiomes, are found. Microorganisms, 9(2): 391. DOI: 10.3390/microorganisms9020391.
Ryazanov V, Duskaev G, Rakhmatullin S, Nurzhanov B & Rysaev A. 2021. Effects of joint and separate uses of the Quercus cortex extract and antibiotics on the microbiome of the broiler intestine. FEBS Open Bio, 11: 385-386. DOI: 10.1002/2211-5463.13205.
Salameh A, Klotz SA & Zangeneh TT. 2012. Disseminated infection caused by Eggerthella lenta in a previously healthy young man: a case report. Case Reports in Infectious Diseases, 2012: 517637. DOI: 10.1155/2012/517637.
Schoch CL, Ciufo S, Domrachev M, Hotton CL, Kannan S, Khovanskaya R, Leipe D, Mcveigh R, O'Neill K, Robbertse B, Sharma S, Soussov V, Sullivan JP, Sun L, Turner S & Karsch-Mizrachi I. 2020. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database, 2020: baaa062. DOI: 10.1093/database/baaa062.
Shajahmetova E, Deryabin D & Duskaev G. 2021. Gamma lactone and vanillic acid change the microbiome of broiler blind appendage. Biotechnology and Biotechnological Equipment, 35(S1): S74. DOI: 10.1080/13102818.2020.1871545.
Shterzer N, Sbehat Y, Poudel B, Rothschild N, Oloko OE, Headrick J, Petersen E, Druyan S & Mills E. 2023. Differences in gut bacterial community composition between modern and slower-growing broiler breeder lines: Implications of growth selection on microbiome composition. Frontiers in Physiology, 14: 1151151. DOI: 10.3389/fphys.2023.1151151.
SILVA. 2025. SILVA rRNA database project. Available online:
Talebi A, Asri-Rezaei S, Rozeh-Chai R & Sahraei R. 2005. Comparative studies on haematological values of broiler strains (Ross, Cobb, Arbor-acres and Arian). International Journal of Poultry Science, 4: 573-579. DOI: 10.3923/ijps.2005.573.579.
Thrall MA, Weiser G, Allison RW & Campbell TW. 2022. Veterinary Hematology, Clinical Chemistry, and Cytology, 3rd ed. Wiley Blackwell, Hoboken, NJ, USA. 1042 Pages.
Tong L, Wang W, Ren S, Wang J, Wang J, Qu Y, Addoma Adam FE, Li Z & Gao X. 2022. The 16S rRNA gene sequencing of gut microbiota in chickens infected with different virulent Newcastle disease virus strains. Animals, 12(19): 2558. DOI: 10.3390/ani12192558.
Wang Q, Garrity GM, Tiedje JM & Cole JR. 2007. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Applied and Environmental Microbiology, 73(16): 5261-5267. DOI: 10.1128/AEM.00062-07.
Wells C, Robertson T, Sheth P & Abraham S. 2024. How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation. Heliyon, 10(12): e32831. DOI: 10.1016/j.heliyon.2024.e32831. | ||
|
آمار تعداد مشاهده مقاله: 4 تعداد دریافت فایل اصل مقاله: 1 |
||
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب